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Research Center Updates
The April 2025 quarterly newsletter features 4 of the CREID Research Centers: CREID-ECA, EpiCenter, PICREID, and WAC-EID. These 4 Research Centers work in the United States as well as in Argentina, Belgium, Cameroon, Democratic Republic of Congo, France, Germany, Kenya, Nigeria, Peru, Senegal, Sierra Leone, and Tanzania, Uganda. Visit our Network Map for the full CREID Network footprint.
Please see more information about each of the 9 Research Centers at the CREID Network website.
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Dr. Philip El Duah, Research Scientist at CUB in Germany, validating the new RVF ELISA test. |
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CREID-ECA
For Rift Valley fever (RVF) disease, a recurrent arboviral disease in sub-Saharan Africa, there are few publicly available serologic diagnostics with good sensitivity and specificity.
CREID-ECA’s partner Charité - Universitätsmedizin Berlin (CUB) in Germany is developing a multi-antigen RVF ELISA assay using recombinant viral nucleoprotein (N), and glycoproteins Gn and Gc that is undergoing validation before rolling out.
A multiplex PCR test assay that can simultaneous detect RVF, dengue virus 1-4, chikungunya, and Zika viruses is also being validated at the Institute of Tropical Medicine in Antwerp, Belgium.
Award Number U01 AI151799
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EpiCenter
The EpiCenter vector studies have demonstrated that different mosquito species dominated each landscape type (forest, forest-edge, and developed areas) at our research sites in Uganda, while a CREID pilot award led by Miguel Garica Knight at National Autonomous University of Mexico (UNAM) identified novel insect specific viruses in understudied Aedes species from mosquitoes collected in Uganda and Mexico. Preliminary findings also suggest that virome diversity in Aedes aegypti is impacted by geography. This work supported a successful application to the Wellcome Trust Infectious Disease Award, where collaborations between scientists at UNAM, the Uganda Virus Research Institute (UVRI), and across EpiCenter will continue.
Award Number U01 AI151814
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Dr. Miguel Garcia Knight hangs a mosquito trap in Uganda. |
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The Investigators of the PICREID DENTHOM study present their results at the final dissemination meeting in April. |
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PICREID
On April 4 th, 2025, Institut Pasteur du Cambodge (IPC) conducted the final dissemination meeting of the DENTHOM study of the PICREID project. The aim of the study was to increase our knowledge on dengue transmission in Cambodia and immunopathology of dengue disease. Information gained by IPC scientists on dengue epidemiology, circulation of the virus, immune responses to dengue, and presence of dengue vectors was shared with local stakeholders, such as the directors and staff of the participating hospitals, the provincial health department of Kampong Thom, the Center for Parasitology, Entomology and Malaria Control, the Cambodian CDC, and representatives of Cambodian Universities. This meeting concludes the 5-year study funded by the NIH/NIAID in the context of the CREID Network.
Award Number U01 AI151758
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WAC-EID
WAC-EID has leveraged the advanced biosafety infrastructure and expertise of the Galveston National Laboratory (GNL) to train West African scientists in high-containment laboratory techniques and infectious disease research. Through this collaboration, GNL has also supported the analysis of samples from West Africa, enhancing regional capacity for disease surveillance, outbreak response and the development of new drugs and vaccines to address these global threats.
Award Number U01 AI151801
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Drs. Robert Cross and Courtney Woolsey are pictured conducting BSL4 containment work. |
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CREID Research Centers
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